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Tissues and Issues

Tissues and Issues

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Lee, J. K. et al. Tension stimulation drives tissue formation in scaffold-free systems. Nat. Mater. 16, 864–873 (2017). https://med.libretexts.org/Bookshelves/Anatomy_and_Physiology/Book%3A_Anatomy_and_Physiology_(Boundless)/20%3A_Immune_System/20.1%3A_Innate_Immunity/20.1B%3A_Phagocytes Mavilio, F. et al. Correction of junctional epidermolysis bullosa by transplantation of genetically modified epidermal stem cells. Nat. Med. 12, 1397–1402 (2006). Each B cell makes one specific antibody. For instance, one might make an antibody against the bacteria that cause pneumonia, and another might recognize the common cold virus. Gosline, J. et al. Elastic proteins: biological roles and mechanical properties. Phil. Trans. R. Soc. Lond. B Biol. Sci. 357, 121–132 (2002).

Schachar, R. A., Chan, R. W. & Fu, M. Viscoelastic properties of fresh human lenses under 40 years of age: implications for the aetiology of presbyopia. Br. J. Ophthalmol. 95, 1010–1013 (2011). Khalilgharibi, N. et al. Stress relaxation in epithelial monolayers is controlled by the actomyosin cortex. Nat. Phys. 15, 839–847 (2019). Pintar, F. A. Geometric and mechanical properties of human cervical spine ligaments. J. Biomed. Eng. 122, 623–629 (2000).Zhang, G. et al. Development of tendon structure and function: regulation of collagen fibrillogenesis. J. Musculoskelet. Neuronal Interact. 5, 5–21 (2005). White blood cells are constantly looking for pathogens. When they find one, they begin to multiply and send signals to other cell types to do the same.

Xi, W., Saw, T. B., Delacour, D., Lim, C. T. & Ladoux, B. Material approaches to active tissue mechanics. Nat. Rev. Mater. 4, 23–44 (2019). Silva, E. D. et al. Multifunctional magnetic-responsive hydrogels to engineer tendon-to-bone interface. Nanomedicine 14, 2375–2385 (2018). Hozic, A., Rico, F., Colom, A., Buzhynskyy, N. & Scheuring, S. Nanomechanical characterization of the stiffness of eye lens cells: a pilot study. Invest. Ophthalmol. Vis. Sci. 53, 2151–2156 (2012). There are four basic tissue types defined by their morphology and function: epithelial tissue, connective tissue, muscle tissue, and nervous tissue. Alcaraz, J. et al. Laminin and biomimetic extracellular elasticity enhance functional differentiation in mammary epithelia. EMBO J. 27, 2829–2838 (2008).Alkhouli, N. et al. The mechanical properties of human adipose tissues and their relationships to the structure and composition of the extracellular matrix. AJP Endocrinol. Metab. 305, E1427–E1435 (2013). Systemic lupus erythematosus. Systemic lupus erythematosus (SLE or simply lupus) is a disease characterized by inflammation of the joints, skin, and internal organs. Symptoms may include:

Norcross, S., Horsley, V., Mertz, A. F., Rosowski, K. A. & Dufresne, E. R. Edges of human embryonic stem cell colonies display distinct mechanical properties and differentiation potential. Sci. Rep. 5, 14218 (2015). McDonald, S. J. et al. Early fracture callus displays smooth muscle-like viscoelastic properties ex vivo: implications for fracture healing. J. Orthop. Res. 27, 1508–1513 (2009). Hu, X. et al. Indirect prediction of liver fibrosis by quantitative measurement of spleen stiffness using the fibroscan system. J. Ultrasound Med. 33, 73–81 (2014).

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Gangadhar, K., Hippe, D. S., Thiel, J. & Dighe, M. Impact of image orientation on measurements of thyroid nodule stiffness using shear wave elastography. J. Ultrasound Med. 35, 1661–1667 (2016). Brezak, R., Hippe, D., Thiel, J. & Dighe, M. K. Variability in stiffness assessment in a thyroid nodule using shear wave imaging. Ultrasound Q. 31, 243–249 (2015).

Localized scleroderma is confined to the skin and, sometimes, the muscle beneath it. Systemic sclerosis also involves the blood vessels and major organs. Yoo, L., Gupta, V., Lee, C., Kavehpore, P. & Demer, J. L. Viscoelastic properties of bovine orbital connective tissue and fat: constitutive models. Biomech. Model. Mechanobiol. 10, 901–914 (2012). Neutrophils: These are also known as granulocytes and provide an early response to inflammation. They kill pathogens but also die as a result.Ozawa, H., Matsumoto, T., Ohashi, T., Sato, M. & Kokubun, S. Comparison of spinal cord gray matter and white matter softness: measurement by pipette aspiration method. J. Neurosurg. Spine 95, 221–224 (2001). Osteogenesis imperfecta . Osteogenesis imperfecta is a condition of brittle bones, low muscle mass, and lax joints and ligaments. There are several types of this condition. Specific symptoms depend on the specific type and may include: Lyshchik, A. et al. Elastic moduli of thyroid tissues under compression. Ultrason. Imaging 110, 101–110 (2005).



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