Singh, S.; Singh, U.; Pandey, S.S. Increased Level of Serum Homocysteine in Vitiligo. J. Clin. Lab. Anal. 2011, 25, 110–112. [ Google Scholar] [ CrossRef] Hwang, Y.J.; Boo, Y.C. Melanogenesis Promotion by 3-Deazaneplanocin A, a Specific Inhibitor of S-Adenosylhomocysteine Hydrolase, in B16/F10 Melanoma Cells. J. Soc. Cosmet. Sci. Korea 2021, 47, 107–121. [ Google Scholar] There was a significant decrease in melanin indices from baseline to end that became evident as early as 2 weeks. The skin lightening effect was observed both in sun-exposed and sun-protected skin.

Researchers conclude that the curcumin found in turmeric may assist in restoring adequate levels of glutathione and improve the activity of glutathione enzymes. One thing I really appreciate about this soap is its high foam. It lathers up well and feels luxurious when you’re using it. It’s also great to know that it doesn’t contain any harmful chemicals, making it friendly to your skin with no side effects.

Conflicts of Interest

Kojic soap can be used at different parts of the body, such as knees, arms, thighs, underarms, and butt. The elbows are often dark; therefore, the kojic acid can make the darker skin brighter. The glutathione soap is valid for the whitening of the skin. The glutathione soap contains natural ingredients, and it is best for producing white complexion.

Serre, C.; Busuttil, V.; Botto, J.M. Intrinsic and extrinsic regulation of human skin melanogenesis and pigmentation. Int. J. Cosmet. Sci. 2018, 40, 328–347. [ Google Scholar] [ CrossRef][ Green Version] Depletion of glutathione in the lungs of alcoholics is most likely due to oxidative stress caused by chronic alcohol use ( 37). Srinivasan, B.; Baratashvili, M.; van der Zwaag, M.; Kanon, B.; Colombelli, C.; Lambrechts, R.A.; Schaap, O.; Nollen, E.A.; Podgorsek, A.; Kosec, G.; et al. Extracellular 4’-phosphopantetheine is a source for intracellular coenzyme A synthesis. Nat. Chem. Biol. 2015, 11, 784–792. [ Google Scholar] [ CrossRef] [ PubMed]

It’s no surprise that many adverse health effects are associated with chronic and excessive alcohol intake.

Oral supplementation of cystine plus glutathione induced a significant skin lightening after 12 weeks. This combination also induced a significant reduction in the size of facial dark spots after 6 and 12 weeks. The changes were significantly bigger than those obtained not only with placebo but also with cystine alone or glutathione alone. Kojic soap and glutathione soap are the best soaps to lighten the skin. Kojic soap plays a significant role in turning the dark color of skin into the white complexion. People who have dark complexion must use Kojic soap because this soap does not harm your skin. Kojic soap neither harms the skin and nor produce any inflammation or irritation on the skin. Chen, J.; Zhuang, T.; Chen, J.; Tian, Y.; Yi, X.; Ni, Q.; Zhang, W.; Song, P.; Jian, Z.; Liu, L.; et al. Homocysteine induces melanocytes apoptosis via PERK-eIF2alpha-CHOP pathway in vitiligo. Clin. Sci. 2020, 134, 1127–1141. [ Google Scholar] [ CrossRef] [ PubMed]Lu, S.C. Glutathione synthesis. Biochim. Biophys. Acta-Gen. Subj. 2013, 1830, 3143–3153. [ Google Scholar] [ CrossRef] [ PubMed][ Green Version]

Hansson, C.; Rorsman, H.; Rosengren, E. 5-S-Cysteinyldopa as a Substrate for Tyrosinase. Acta Dermatol. Venereol. 1980, 60, 399–402. [ Google Scholar] According to the reviewers, the available data suggest that the use of products containing kojic acid with a concentration of 2 percent for products left on the skin is considered safe. Thody, A.J.; Higgins, E.M.; Wakamatsu, K.; Ito, S.; Burchill, S.A.; Marks, J.M. Pheomelanin as Well as Eumelanin Is Present in Human Epidermis. J. Investig. Dermatol. 1991, 97, 340–344. [ Google Scholar] [ CrossRef] [ PubMed][ Green Version]People should not use kojic acid on skin that is already red or irritated. It should also not be used on broken skin. However, this link was weak since kojic acid is slowly absorbed into the circulation. It is unlikely that levels would become high enough to cause cancer in humans.